Maxime Mahé (CRCN Inserm UMR1235 TENS), Laurent David (scientific manager PF iPSCDTC) and their collaborators have just won the “Research Infrastructures” call for projects initiated by the Pays de la Loire Region. This project will be managed by the University of Nantes and coordinated by UMS BioCore.

The Organoids Infrastructure of Nantes will enable the application of advanced technologies in the service of excellence in health research. The Pays de la Loire region supports this establishment with 586,645 euros from a total budget of 977,742 euros for a period of 3 years.

Organoids face 2 main problems: Better understand the mechanisms at work in pathologies and consider individual treatments.

The project, hosted on the Nantes website, aims to develop a distributed platform offering organ models to the scientific community and healthcare companies. regionally as well as nationally.

General context

Research in biology and health is based on the use of models. They allow us to understand the processes of development, physiology or pathologies with the aim of improving the duration and quality of life, especially human life. While limiting the use of animal models, the development of systems and models that are more representative of the human species is an area of ​​intense activity. A big innovation, that is organellesincorporates growing expertise in stem cell culture tools, cell differentiation control, and multiscale culture technologies.

Organoids

An organoid is a miniaturized and simplified version of an organ derived from one or more adult, pluripotent, or cancer stem cells. These cells form a three-dimensional organelle due to their ability to self-organize and differentiate. Depending on the cells used for To establish a culture, the organelle can regenerate single or multiple tissues with microtomies similar to any organ.

Thus, organelles allow a greater representation of the physiology of organs, the response to drug treatment, and enable the study of diseases.

These allow testing therapeutic approaches and pave the way for personalized medicine. Finally, their use is part of the 3R ethical approach (Replace, Reduce, Clean) where their use will greatly reduce the use of animal models.

((for more information, an infographic in English is available here)

Infrastructure issues

Although organoid models provide significant added value in basic, translational, and clinical research, their creation and use require new skills, know-how, and specialized equipment. Based on existing site capabilities, this project will allow structuring them into a set of platforms distributed across the site but brought together in a common infrastructure, offering the visibility needed for this technology, building different capabilities, building modules into existing platforms, etc. strengthen the use of organelle models.

This infrastructure project is led by:

Maxim MAHE, CRCN Inserm – UMR1235 TENS (Inserm-NU):
and Laurent DAVID, MCU-PH CHU Nantes resp. scholar PF iPSCDTC – UMS BioCore (Inserm-NU-CNRS-CHU Nantes)

with:

  • Hervé BLOTTIERE – UMR1280 PhAN (Inrae-NU)
  • Amandine CAILLAUD / Richard REDON – UMR1087/UMR6291 ITx (Inserm-NU-CNRS)
  • Vianney DELPLACE / François LOLL – UMR1229 RMeS (Inserm-NU-ONIRIS)
  • Jean-Baptiste DUPONT / Oumeya ADJALI – UMR1089 TaRGeT (Inserm-NU)
  • Vincent GUEN / Christophe BLANQUART – UMR1307/UMR6075 CRCI2NA (Inserm-NU-CNRS)
  • Anne JARRY / Caroline VIGNES – UMR1302/EMR 6001 INCIT (Inserm-NU-CNRS)
  • Jérôme JULLIEN / Matthieu GIRAUD – UMR1064 CR2TI (Inserm-NU)
  • Michel NEUNLIST – UMR1235 TENS (Inserm-NU)
Coordination:
BioCore logo

biocore trustee logos

Major funder:

Region logo